BARD1
BRCA1 associated RING domain 1
Synonyms:
Species:
Human BARD1 (580), Mouse Bard1 (12021), Rat Bard1 (64557), Zebrafish bard1 (333951), cow BARD1 (530961), Horse BARD1 (100053962), domestic cat BARD1 (101080728), dog BARD1 (610190), chicken BARD1 (424010), Thale Cress BARD1 (839329) ...More
UniProtKB ID:
Gene ID:
- Human(580) Summary: This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer. [provided by RefSeq, Jul 2008]
- Mouse(12021) BRCA1 associated RING domain 1
- Rat(64557) BRCA1 associated RING domain 1
- Zebrafish(333951) BRCA1 associated RING domain 1
- cow(530961) BRCA1 associated RING domain 1
- Horse(100053962) BRCA1 associated RING domain 1
- domestic cat(101080728) BRCA1 associated RING domain 1
- dog(610190) BRCA1 associated RING domain 1
- chicken(424010) BRCA1 associated RING domain 1
- Thale Cress(839329) BRCA1-associated RING domain protein 1
- sheep(101108373) BRCA1 associated RING domain 1
- domestic guinea pig(100731860) BRCA1 associated RING domain 1
- naked mole-rat(101722439) BRCA1 associated RING domain 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-BARD1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-BARD1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
Rabbit anti-BARD1 Antibody, Affinity Purified, Powered by Bethyl Laboratories, Inc.,
Species Reactivity
human
Application
immunoprecipitation (IP)
western blot
western blot