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Merck

ATF6

activating transcription factor 6

Synonymes:
ATF6A
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(22926) Summary: This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011]
  • Mouse(226641) activating transcription factor 6
  • Rat(304962) activating transcription factor 6
  • Zebrafish(558071) activating transcription factor 6
  • cow(530610) activating transcription factor 6
  • Horse(100051169) activating transcription factor 6
  • domestic cat(101086780) activating transcription factor 6
  • dog(488660) activating transcription factor 6
  • chicken(424365) activating transcription factor 6
  • fruit fly(35480) CG3136 gene product from transcript CG3136-RA
  • sheep(541606) activating transcription factor 6
  • Domestic Rabbit(100358536) activating transcription factor 6
  • domestic guinea pig(100730337) activating transcription factor 6
  • naked mole-rat(101706597) activating transcription factor 6

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Antibodies

Référence du produit
Description
Espèces réactives
Application
Anti-ATF6 Antibody, Upstate®, from rabbit,
Espèces réactives
human
Application
western blot
Anti-ATF6 antibody produced in rabbit, ,
Espèces réactives
human, mouse, rat
Application
immunofluorescence
immunohistochemistry

western blot
Anti-ATF6α Antibody, clone 1F11 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Espèces réactives
human, monkey
Application
ELISA
affinity binding assay

immunohistochemistry

western blot
Anti-ATF6 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry
Anti-ATF6 (ab1) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Espèces réactives
human, mouse
Application
ELISA
immunocytochemistry

immunofluorescence

immunohistochemistry

western blot

esiRNA

Référence du produit
Description
Espèce(s)
MISSION® esiRNA, targeting mouse Atf6,
Espèce(s)
mouse
MISSION® esiRNA, targeting mouse Atf6,
Espèce(s)
mouse
MISSION® esiRNA, targeting human ATF6,
Espèce(s)
human