ARNT
aryl hydrocarbon receptor nuclear translocator
Synonyms:
HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2
Species:
Human ARNT (405), Mouse Arnt (11863), Rat Arnt (25242), Zebrafish arnt (493634), cow ARNT (281010), domestic cat ARNT (101093627), dog ARNT (483185), chicken ARNT (374026), naked mole-rat Arnt (101717560), domestic guinea pig Arnt (100379223)
UniProtKB ID:
Gene ID:
- Human(405) Summary: The aryl hydrocarbon (Ah) receptor is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the Ah receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in translocation of the ligand-binding subunit only to the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound Ah receptor to xenobiotic responsive elements in the promoters of genes for these enzymes. This gene encodes a protein that forms a complex with the ligand-bound Ah receptor, and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1. A t(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]
- Mouse(11863) aryl hydrocarbon receptor nuclear translocator
- Rat(25242) aryl hydrocarbon receptor nuclear translocator
- Zebrafish(493634) aryl hydrocarbon receptor nuclear translocator
- cow(281010) aryl hydrocarbon receptor nuclear translocator
- domestic cat(101093627) aryl hydrocarbon receptor nuclear translocator
- dog(483185) aryl hydrocarbon receptor nuclear translocator
- chicken(374026) aryl hydrocarbon receptor nuclear translocator
- naked mole-rat(101717560) aryl hydrocarbon receptor nuclear translocator
- domestic guinea pig(100379223) aryl hydrocarbon receptor nuclear translocator
- sheep(443285) aryl hydrocarbon receptor nuclear translocator
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-ARNT antibody produced in mouse, clone 3D10, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Monoclonal Anti-ARNT, (N-terminal) antibody produced in mouse, clone 1F12, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-ARNT Antibody, clone 1H2 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
canine, feline, human, monkey, mouse, porcine, rat
Application
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Anti-ARNT antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
immunofluorescence
western blot
western blot
Anti-ARNT antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
immunohistochemistry