ANK1
ankyrin 1, erythrocytic
Synonyms:
ANK, SPH1, SPH2
Species:
Human ANK1 (286), Mouse Ank1 (11733), Rat Ank1 (306570), naked mole-rat Ank1 (101714665), domestic guinea pig Ank1 (100725822), sheep ANK1 (101121569), Zebrafish ank1 (449796), cow ANK1 (353108), Horse ANK1 (100055459), dog ANK1 (482842) ...More
UniProtKB ID:
Gene ID:
- Human(286) Summary: Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified. [provided by RefSeq, Dec 2008]
- Mouse(11733) ankyrin 1, erythroid
- Rat(306570) ankyrin 1, erythrocytic
- naked mole-rat(101714665) ankyrin 1, erythrocytic
- domestic guinea pig(100725822) ankyrin 1, erythrocytic
- sheep(101121569) ankyrin 1, erythrocytic
- Zebrafish(449796) ankyrin 1, erythrocytic
- cow(353108) ankyrin 1, erythrocytic
- Horse(100055459) ankyrin 1, erythrocytic
- dog(482842) ankyrin 1, erythrocytic
- chicken(396311) ankyrin 1, erythrocytic
- Thale Cress(831855) protein ankyrin-like1
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-ANK1 antibody produced in mouse, clone 3C3, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunoprecipitation (IP)
immunoprecipitation (IP)
Monoclonal Anti-Ankyrin R-PerCP antibody produced in mouse, clone S388A-10,
Species Reactivity
human, rat
Application
immunofluorescence
western blot
western blot
Monoclonal Anti-Ankyrin R-Atto 390 antibody produced in mouse, clone S388A-10,
Species Reactivity
human, rat
Application
immunofluorescence
western blot
western blot
Monoclonal Anti-Ankyrin R-Biotin antibody produced in mouse, clone S388A-10,
Species Reactivity
human, rat
Application
immunofluorescence
western blot
western blot
Monoclonal Anti-Ankyrin R-Atto 488 antibody produced in mouse, clone S388A-10,
Species Reactivity
human, rat
Application
immunofluorescence
western blot
western blot
esiRNA
Product Number
Description
Species