ADD3
adducin 3 (gamma)
Synonyms:
ADDL
Species:
Human ADD3 (120), Mouse Add3 (27360), Rat Add3 (25230), chicken ADD3 (373892), cow ADD3 (505225), Horse ADD3 (100059447), domestic cat ADD3 (101091902), dog ADD3 (486881), naked mole-rat Add3 (101715401), domestic guinea pig Add3 (100735302)
UniProtKB ID:
Gene ID:
- Human(120) Summary: Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced adducin gamma transcripts encoding different isoforms have been described. The functions of the different isoforms are not known. [provided by RefSeq, Jul 2008]
- Mouse(27360) adducin 3 (gamma)
- Rat(25230) adducin 3 (gamma)
- chicken(373892) adducin 3 (gamma)
- cow(505225) adducin 3 (gamma)
- Horse(100059447) adducin 3 (gamma)
- domestic cat(101091902) adducin 3 (gamma)
- dog(486881) adducin 3 (gamma)
- naked mole-rat(101715401) adducin 3 (gamma)
- domestic guinea pig(100735302) adducin 3 (gamma)
- sheep(101117808) adducin 3 (gamma)
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-phospho-Adducin (Ser662) Antibody, Upstate®, from rabbit,
Species Reactivity
canine, human, mouse, rat
Application
western blot
Anti-ADD3 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Application
ELISA
western blot
western blot
Anti-ADD3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot