SAB5702261

Anti-MCM2 Antibody, clone 0Q10S9, Rabbit Monoclonal

• Synonym(s): MCM2,BM28,CCNL1,CDCL1,D3S3194,DFNA70,MITOTIN,cdc19
• UNSPSC Code: 12352203
• NACRES: NA.46

Properties

• biological source: rabbit
• Quality Level: 100
• material: colorless
• clone: 0Q10S9, monoclonal
• form: liquid
• mol wt: 125 kDa
• species reactivity: human, rat, rat
• concentration: 0.38 mg/mL
• technique(s): immunofluorescence: 1:50 - 1:200; immunohistochemistry: 1:100 - 1:200; western blot: 1:500 - 1:2000
• color: colorless
• isotype: IgG
• immunogen sequence: MAESSESFTMASSPAQRRRGNDPLTSSPGRSSRRTDALTSSPGRDLPPFEDESEGLLGTEGPLEEEEDGEELIGDGMERDYRAIPELDAYEAEGLALDDE
• UniProt accession no.: P49736
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... MCM2(4171)

Description

General description

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined.

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MCM2 (P49736).

PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

Application

WB, IHC, IF/ICC

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1