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1009005

USP

Acetylcysteine

United States Pharmacopeia (USP) Reference Standard

Sinónimos:

N-Acetyl-L-cysteine, LNAC, NAC

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About This Item

Fórmula lineal:
HSCH2CH(NHCOCH3)CO2H
Número de CAS:
616-91-1
Peso molecular:
163.19
Beilstein/REAXYS Number:
1724426
MDL number:
MFCD00004880
UNSPSC Code:
41116107
PubChem Substance ID:
329748885
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

acetylcysteine

manufacturer/tradename

USP

mp

106-108 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CC(=O)N[C@@H](CS)C(O)=O

InChI

1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)/t4-/m0/s1

InChI key

PWKSKIMOESPYIA-BYPYZUCNSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Acetylcysteine USP reference standard intended for use in specified compendial tests and assays.

Also used to prepare standard stock and standard solution for assay by using the liquid chromatography method in conjunction with uv detector according to the given below monographs of United States Pharmacopeia (USP):
  • Acetylcysteine Solution
  • Acetylcysteine
  • Acetylcysteine Compounded Solution

Biochem/physiol Actions

Antioxidant and mucolytic agent. Increases cellular pools of free radical scavengers. Reported to prevent apoptosis in neuronal cells but induce apoptosis in smooth muscle cells. Inhibits HIV replication. May serve as a substrate for microsomal glutathione transferase.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Acetylcysteine Solution
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 27(3), 82-82 (2020)
Yuval Samuni et al.
Biochimica et biophysica acta, 1830(8), 4117-4129 (2013-04-27)
N-acetylcysteine (NAC) has been in clinical practice for several decades. It has been used as a mucolytic agent and for the treatment of numerous disorders including paracetamol intoxication, doxorubicin cardiotoxicity, ischemia-reperfusion cardiac injury, acute respiratory distress syndrome, bronchitis, chemotherapy-induced toxicity
Anna M Sadowska
Therapeutic advances in respiratory disease, 6(3), 127-135 (2012-03-01)
To develop an efficient therapy for chronic obstructive pulmonary disease (COPD), N-acetylcysteine (NAC) has been tested as a medication that can suppress various pathogenic processes in this disease. NAC is a thiol compound, which provides sulfhydryl groups. NAC can act
Javed Akhter et al.
American journal of cancer research, 4(5), 495-507 (2014-09-19)
Compared to current treatment for pseudomyxoma peritonei (PMP), the extraction of solubilised mucin through peritoneal catheter can be minimally invasive. However, mucin has variable appearance that may influence mucolysis. Hence, we investigated the mucolysis of 36 mucin samples with a
Gaurav Sharma et al.
Nanotoxicology, 8(6), 663-675 (2013-07-11)
Spontaneous agglomeration of engineered nanoparticles (ENPs) is a common problem in cell culture media which can confound interpretation of in vitro nanotoxicity studies. The authors created stable agglomerates of iron oxide nanoparticles (IONPs) in conventional culture medium, which varied in
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