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Key Documents

P3982

Sigma-Aldrich

[Pro34]-Peptide YY

≥95%

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About This Item

Fórmula empírica (notación de Hill):
C194H294N54O56
Peso molecular:
4278.74
MDL number:
MFCD00166246
UNSPSC Code:
12352209
NACRES:
NA.77

Quality Level

200

assay

≥95%

form

powder

UniProt accession no.

P10082

storage temp.

−20°C

Gene Information

human ... PYY(5697)

Amino Acid Sequence

Tyr-Pro-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Pro-Arg-Tyr-NH2

General description

Peptide YY (PYY) is synthesized by L cells in the mucosa of the distal ileum, colon, and rectum. It is mainly expressed by peripheral blood mononuclear cells. Peptide YY is located on human chromosome 17q21.

Biochem/physiol Actions

Peptide YY (PYY) is involved in the modulation of gut motility, food intake and insulin secretion and is associated with obesity and type 2 diabetes. It may possess systemic and paracrine functions. NPY agonist with a preference for the Y1 and Y5 subtypes.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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N D Holliday et al.
Canadian journal of physiology and pharmacology, 78(2), 126-133 (2000-03-29)
This investigation describes the relative potencies of four peptide agonists, namely, peptide YY (PYY), [Leu3l,Pro34]PYY (Pro34pYY), neuropeptide Y (NPY), and [Leu31,Pro34]NPY (Pro34NPY), as antisecretory agents in human, rat, and mouse gastrointestinal preparations. The inhibition of agonist responses by the Y1-receptor
TLR ligands and butyrate increase Pyy expression through two distinct but inter-regulated pathways
Larraufie P, et al.
Cellular Microbiology, 19(2), e12648-e12648 (2017)
K Kawakubo et al.
Brain research, 854(1-2), 30-34 (2000-04-28)
We previously reported that intracisternal (i.c.) injection of peptide YY (PYY) and low doses of thyrotropin-releasing hormone (TRH) or TRH analog, RX 77368, increased the resistance of the gastric mucosa to ethanol injury through vagal pathways in rats. The gastroprotective
Julia Pia Natascha Holler et al.
Peptides, 58, 78-82 (2014-06-28)
Peptide YY is produced by L cells in the mucosa of the distal ileum, colon, and rectum and may have systemic and paracrine functions. We hypothesized that peptide YY is expressed by peripheral blood mononuclear cells. The purpose of the
Y Hort et al.
Genomics, 26(1), 77-83 (1995-03-01)
Neuropeptide Y (NPY), peptide YY (PYY), and pancreatic polypeptide (PP) are structurally related but functionally diverse peptides, encoded by separate genes and expressed in different tissues. Although the human NPY gene has been mapped to chromosome 7, we demonstrate here

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