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Key Documents

O1641

Sigma-Aldrich

Ovalbumin (323-339) (chicken, Japanese quail)

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.26

assay

97-100% (HPLC)

Quality Level

form

lyophilized powder

composition

peptide content, 65-100%

color

white

solubility

water, double-distilled: soluble

storage temp.

−20°C

Amino Acid Sequence

H-Ile-Ser-Gln-Ala-Val-His-Ala-Ala-His-Ala-Glu-Ile-Asn-Glu-Ala-Gly-Arg-OH

General description

Ovalbumin (323-339) is an egg white protein surrounded by B-cell epitopes, which are bound by specific IgE antibodies. In addition to this, it also contains CD4+ T cell epitopes.
The peptide is a major MHC class II-restricted T-cell epitope of Ovalbumin which is used for studies of immunological allergic responses such as asthma, food allergy and more..

Application

Ovalbumin (323-339) (chicken, Japanese quail) has been used to induce allergic asthma in mice.

Biochem/physiol Actions

Ovalbumin (OVA) peptide 323-339 mediates 25–35% of T-cell response to intact OVA in isolated BALB/c mouse. OVA 323-339 has been widely used to determine the characteristics of class II major histocompatibility complex (MHC)-peptide binding and T-cell activation.
With the help of two functionally distinct registers ovalbumin (323-339) peptide can bind to histocompatibility complex class II I-A(d) protein.

Physical form

Lyophilized from 0.1% aqueous TFA

Other Notes

Lyophilized from 0.1% TFA in H2O

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

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ORMDL3 may participate in the pathogenesis of bronchial xn-epithelialmesenchymal-1e9l transition in asthmatic mice with airway remodeling
Cheng Q, et al.
Molecular Medicine Reports, 17(1), 995-1005 (2018)
Ovalbumin(323-339) peptide binds to the major histocompatibility complex class II I-A(d) protein using two functionally distinct registers
McFarland BJ, et al.
Biochemistry, 38(50), 16663-16670 (1999)
Weifang Wang et al.
Frontiers in nutrition, 9, 931427-931427 (2022-08-02)
Asthma is a chronic disease, which is harmful to the health of the body and the quality of life. Supplementation of Lactobacillus can affect the immune environment of the lungs through the gut-lung axis. This study aimed to explore the
Min Liu et al.
Immunity, inflammation and disease, 11(2), e730-e730 (2023-02-18)
Asthma is a chronic respiratory disease with an increasing incidence every year. microRNAs (miRNAs) have been demonstrated to have implications for asthma. However, limited information is available regarding the effect of miR-124-3p on this disease. Therefore, this study aimed to
Haruyo Nakajima-Adachi et al.
Bioscience, biotechnology, and biochemistry, 76(10), 1979-1981 (2012-10-11)
The epitopes for OVA323-339-specific CD4⁺T cells from OVA23-3 food allergy model and DO11.10 tolerant induction model mice were analyzed. We found that OVA23-3 CD4⁺T cells recognized the N-terminal region, showing strong proliferation and the Th2-phenotype, and that DO11.10 CD4⁺T cells

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