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I5396

Sigma-Aldrich

IL-1α mouse

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Sinónimos:

mIL-1α, IL-1α

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About This Item

MDL number:
MFCD00164814
UNSPSC Code:
12352202
NACRES:
NA.77

product name

Interleukin-1α from mouse, IL-1α, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

biological source

mouse

Quality Level

100

recombinant

expressed in E. coli

assay

≥97% (SDS-PAGE)

form

lyophilized powder

potency

3-7 pg/mL ED50

quality

endotoxin tested

mol wt

18 kDa

packaging

pkg of 5 and 25 μg

technique(s)

cell culture | mammalian: suitable

impurities

<0.1 EU/μg

UniProt accession no.

P01583

storage temp.

−20°C

Gene Information

mouse ... IL1A(3552)

Biochem/physiol Actions

Interleukin-1 (IL-1), originally known as Lymphocyte Activating Factor (LA F), activates T cells and lymphocytes, which then proliferate and secrete Interleukin-2 (IL-2). The proliferative activity of human IL-1α is tested in culture using the murine cell line D10S.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.25 mg bovine serum albumin.

Analysis Note

The biological activity is measured in a cel proliferation assay using the murine helper T cell line, D10.G4.1.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Katiria Soto-Díaz et al.
Journal of neurochemistry, 152(6), 697-709 (2019-11-30)
Systemic inflammation can exacerbate symptoms of many neurological diseases. This effect may be facilitated by glial cells of the central nervous system (CNS) that alter their transcriptional responses and up-regulate cytokine and chemokine expression which can, in turn trigger immune
Symons, J.A., et al. et al.
Lymphokines and Interferons, A Practical Approach, 272-272 (1987)

Artículos

Interleukin Family (IL)

The Interleukins comprise a disparate group of cytokines and growth factors that are produced by and released from leukocytes. Interleukin-1β (1L-1β) is released primarily from stimulated macrophages and monocytes and plays a key role in inflammatory and immune responses and may induce anti-tumor immunity.

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