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G9144

Sigma-Aldrich

Anti-Gliadin (Wheat) antibody produced in rabbit

fractionated antiserum, buffered aqueous solution

Sinónimos:

Anti-Gliadin (Wheat)

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About This Item

MDL number:
MFCD00162321
UNSPSC Code:
12352203
NACRES:
NA.46

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

fractionated antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

wheat

technique(s)

dot blot: 1:1,500
indirect ELISA: 1:5,000

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

wheat ... LOC543191(543191) , LOC543191(543191) , Loc543191(543191)

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General description

Gliadin is a protein found in wheat and other cereals. The T cells recognize the gliadin epitopes and activate the innate immune response similar to the response to pathogens. This response is more intense in coeliac disease wherein the gut-derived T cells produced in response to gliadin induce damage to the small intestine. Therefore, patients affected by coeliac disease or gluten-sensitivity should avoid food that produce gliadin
Gliadin is an important component of wheat gluten. It is composed of single-chain polypeptides and has a molecular weight of 25−100 kDa. It is associated by intramolecular disulfide bonds.

Specificity

Rabbit Anti-Gliadin shows specificity for native wheat gliadin.

Immunogen

native and heat-treated wheat gliadin

Application

Anti-Gliadin (Wheat) antibody produced in rabbit has been used in immunoblot and enzyme-linked immunosorbent assay (ELISA).

Biochem/physiol Actions

Gliadin is a class of glutamine containing, alcohol soluble proteins separable from wheat and rye glutens known as the prolamins. These proteins are associated with the harmful effects of celiac disease and gluten sensitive enteropathy in humans, causing characteristic changes in the small intestinal mucosa. In such cases, strict compliance to a gluten-free diet is usually recommended.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Luigi Maiuri et al.
Lancet (London, England), 362(9377), 30-37 (2003-07-11)
The adaptive immune system is central to the development of coeliac disease. Adaptive immune responses are, however, controlled by a preceding activation of the innate immune system. We investigated whether gliadin, a protein present in wheat flour, could activate an
A Mustafa et al.
Annals of medicine, 33(2), 103-112 (2001-05-01)
Circulating immune complexes (CIC) are frequently found in postinfarction patients. The constituents of these CIC are mostly unknown. The objective of the current study was to assess whether CIC containing alimentary proteins and antibodies against these proteins are implicated in
Tarja A Kemppainen et al.
Scandinavian journal of gastroenterology, 43(9), 1094-1101 (2008-07-09)
There is evidence for the long-term safety of oats as part of a gluten-free diet in coeliac disease (CD). Oats is generally processed by kilning, which theoretically may change its antigenic properties and be the reason that it is tolerated
Vincent P Jones et al.
Journal of insect science (Online), 11, 87-87 (2011-08-30)
Immunomarking systems used to track large-scale movement patterns of insects are highly dependent on the efficiency of the enzyme linked imunosorbent assay (ELISA) reaction and logistical factors (e.g. concentration of marker applied, ability of the marker to wet the insect
Determination of Prolamins in Beers by ELISA and SDS-PAGE
Kanerva P, et al.
Journal of the Institute of Brewing, 111(1), 61-64 (2005)
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