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Key Documents

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D9815

Sigma-Aldrich

Doxazosin mesylate

≥97% (HPLC), powder

Sinónimos:

1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[4-(1,4-benzodioxan-2-yl)carpiperazin-1-yl)]-6,7-dimethoxyquinazoline mesylate, Doxazosin methanesulfonate

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About This Item

Fórmula empírica (notación de Hill):
C23H25N5O5 · CH3SO3H
Número de CAS:
77883-43-3
Peso molecular:
547.58
MDL number:
MFCD00216023
UNSPSC Code:
12352200
PubChem Substance ID:
24278398
NACRES:
NA.77

assay

≥97% (HPLC)

form

powder

color

white

SMILES string

CS(O)(=O)=O.COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)C4COc5ccccc5O4

InChI

1S/C23H25N5O5.CH4O3S/c1-30-18-11-14-15(12-19(18)31-2)25-23(26-21(14)24)28-9-7-27(8-10-28)22(29)20-13-32-16-5-3-4-6-17(16)33-20;1-5(2,3)4/h3-6,11-12,20H,7-10,13H2,1-2H3,(H2,24,25,26);1H3,(H,2,3,4)

InChI key

VJECBOKJABCYMF-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146)
rat ... Adra1a(29412) , Adra1b(24173) , Adra1d(29413)

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Biochem/physiol Actions

α1-adrenoceptor antagonist; relaxes smooth muscles of the prostate

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

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Evan Goldfischer et al.
Urology, 79(4), 875-882 (2012-02-22)
To investigate the safety of daily coadministration of α-blockers with tadalafil 5 mg in men with lower urinary tract symptoms secondary to benign prostatic hyperplasia. The standard-of-care medical therapy for moderate to severe symptoms of benign prostatic hyperplasia is α(1)-adrenergic
Giovanni Conzo et al.
The American surgeon, 79(11), 1196-1202 (2013-10-30)
Authors evaluated the effects of selective adrenergic blockade by means of doxazosin on blood pressure in 48 patients operated on for pheochromocytoma by a multicenter retrospective study. Age, tumor size, surgical approach, and operative time were analyzed as predictive factors
Flávia K Delella et al.
Life sciences, 91(25-26), 1281-1287 (2012-10-17)
To gain new insights into the molecular mechanisms of action of doxazosin, we investigated the prostatic stroma ultrastructure and the expression of genes involved with fibrosis, such as collagen type I and III (COL1A1 and COL3A1, respectively) and TGF-beta 1
Cédric M Hysek et al.
Psychopharmacology, 224(3), 363-376 (2012-06-16)
Pupillometry can be used to characterize autonomic drug effects. This study was conducted to determine the autonomic effects of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy), administered alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin, on pupillary function. Infrared pupillometry was
Giovanni Conzo et al.
International journal of surgery (London, England), 11(2), 152-156 (2012-12-27)
Minimally invasive adrenalectomy for pheochromocytoma (PCC) is a complex surgical procedure especially because of the haemodynamic instability due to the excessive secretion of cathecolamines, which may result in a considerable risk of conversion and complications. By a multicentric retrospective study
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