Saltar al contenido
MilliporeSigma
Todas las fotos(1)

Key Documents

View All Documentation

SML0136

Sigma-Aldrich

TGN-020

≥98% (HPLC)

Sinónimos:

2-(Nicotinamide)-1,3,4-thiadiazole, N-(1,3,4-Thiadiazol-2-yl)-3-pyridinecarboxamide, N-(1,3,4-Thiadiazol-2-yl)pyridine-3-carboxamide, N-(1,3,4-Thiadiazolyl)-m-nicotinamide

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Todas las fotos(1)

About This Item

Fórmula empírica (notación de Hill):
C8H6N4OS
Número de CAS:
51987-99-6
Peso molecular:
206.22
MDL number:
MFCD00708771
UNSPSC Code:
12352200
PubChem Substance ID:
329825185
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: ≥8 mg/mL

storage temp.

room temp

SMILES string

O=C(Nc1nncs1)c2cccnc2

InChI

1S/C8H6N4OS/c13-7(6-2-1-3-9-4-6)11-8-12-10-5-14-8/h1-5H,(H,11,12,13)

InChI key

AGEGZHOPKZFKBP-UHFFFAOYSA-N

Application

Beas2B human lung epithelial cells were treated with TGN-020 to study the effect on cigarette smoke extracts-induced CCN1 secretion.

Biochem/physiol Actions

TGN-020 is an inhibitor of Aquaporin 4 (AQP4), the most abundant water channel in brain. Aquaporins (AQPs) are water channels required for maintaining fluid homeostasis and enabling water movement across barrier membranes, but can enhance pathological cellular volume changes and cause edema in injury states. Pretreatment with the AQP4 inhibitor TGN-020 significantly reduced the volume of brain edema associated with ischemic injury in a mouse model of focal cerebral ischemia.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Hyung-Geun Moon et al.
PloS one, 8(7), e68199-e68199 (2013-07-23)
Inflammation involves in many cigarette smoke (CS) related diseases including the chronic obstructive pulmonary disease (COPD). Lung epithelial cell released IL-8 plays a crucial role in CS induced lung inflammation. CS and cigarette smoke extracts (CSE) both induce IL-8 secretion
Hiromu Monai et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(22), 11010-11019 (2019-05-18)
Spontaneous waves of cortical spreading depolarization (CSD) are induced in the setting of acute focal ischemia. CSD is linked to a sharp increase of extracellular K+ that induces a long-lasting suppression of neural activity. Furthermore, CSD induces secondary irreversible damage
Jian Li et al.
Brain research bulletin, 170, 162-173 (2021-02-17)
The extracellular signal-regulated kinase (ERK) pathway has been reported to play a pivotal role in mediating spinal cord injury (SCI) progression. The present study aimed to investigate the effects of phosphorylated ERK1/2 (p-ERK1/2) inhibition on SCI-induced astrocyte activation and inflammation
Cheng Guo et al.
Inflammation, 42(4), 1401-1412 (2019-04-05)
Acute lung injury (ALI) is a syndrome characterized by damage to the alveolar-capillary wall, pulmonary edema and recruitment of inflammatory cells. Previous studies have indicated that aquaporin 4 (AQP4) plays a key role in brain edema formation and resolution. However
Yuji Suzuki et al.
Neurosurgery, 82(6), 842-846 (2017-06-25)
Aquaporin (AQP) water channels play a significant role in mesenchymal microvascular proliferation and infiltrative growth. AQPs are highly expressed in malignant astrocytomas, and a positive correlation is observed between their expression levels and histological tumor grade. To examine the utility
Ver todos los artículos relacionados

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico