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352A-7

Sigma-Aldrich

Napsin A Rabbit Polyclonal Antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
En este momento no podemos mostrarle ni los precios ni la disponibilidad

biological source

rabbit

Quality Level

100
500

conjugate

unconjugated

antibody form

Ig fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (352A-74)
vial of 0.5 mL concentrate (352A-75)
bottle of 1.0 mL predilute (352A-77)
vial of 1.0 mL concentrate (352A-76)
bottle of 7.0 mL predilute (352A-78)

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Este artículo
F36511.0415734321-M
Fluorescein isothiocyanate isomer I suitable for protein labeling, ≥90% (HPLC), powder

F7250

Fluorescein isothiocyanate isomer I

Fluorescein 5(6)-isothiocyanate ≥90% (HPLC)

F3651

Fluorescein 5(6)-isothiocyanate

Fluorescein-5-isothiocyanate (FITC)

1.04157

Fluorescein-5-isothiocyanate (FITC)

FITC, Isomer I

34321-M

FITC, Isomer I

suitability

suitable for protein labeling

suitability

-

suitability

-

suitability

-

color

orange to dark orange

color

yellow to orange

color

-

color

orange-red

fluorescence

λex 492 nm; λem 518 nm (green)

fluorescence

-

fluorescence

-

fluorescence

-

application(s)

diagnostic assay manufacturing
hematology
histology

application(s)

diagnostic assay manufacturing
hematology
histology

application(s)

diagnostic assay manufacturing
hematology
histology

application(s)

-

form

powder

form

powder

form

-

form

solid

General description

Napsin is a pepsin-like aspartic proteinase, in the A1 clan of the AA clade of proteinases. There are two closely related napsins, napsin A and napsin B. Napsin A is expressed as a single chain protein with the molecular weight of approximately 38 kDa. Immunohistochemical studies revealed high expression levels of napsin A in human lung and kidney but low expression in spleen. Napsin A is expressed in type II pneumocytes and in adenocarcinomas of lung. The high specificity expression of napsin A in adenocarcinomas of lung is useful to distinguish primary lung adenocarcinomas from adenocarcinomas of other organs.[1][2][3][4][5]

Quality


IVD
IVD
IVD
RUO

Linkage

Napsin A Positive Control Slides, Product No. 352S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

    • Elija entre una de las versiones más recientes:

    Certificados de análisis (COA)

    Lot/Batch Number
    0000295654
    0000299048
    0000293557
    0000299048
    0000295654

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    Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

    Visite la Librería de documentos

    Jaishree Jagirdar
    Archives of pathology & laboratory medicine, 132(3), 384-396 (2008-03-06)
    Immunohistochemistry is a very valuable and often used tool in the differential diagnosis of lung carcinomas whether primary or secondary to the lung. The most useful application is in distinguishing primary lung tumors from metastatic tumors to the lung from
    Justin A Bishop et al.
    Human pathology, 41(1), 20-25 (2009-09-11)
    Recent advances in the treatment of pulmonary adenocarcinoma have increased the need for accurate typing of non-small cell carcinomas. Immunohistochemistry for thyroid transcription factor-1 is widely used in the diagnosis of pulmonary adenocarcinomas because it marks approximately 75% of lung
    Jiqing Ye et al.
    Applied immunohistochemistry & molecular morphology : AIMM, 19(4), 313-317 (2011-04-06)
    Differentiation of primary from metastatic adenocarcinoma in the lung can be challenging, and it demands sensitive and specific biomarkers, especially when the tissue for diagnosis is limited. Thyroid transcription factor-1 (TTF-1) has been considered a reliable marker for adenocarcinoma of
    Annika Dejmek et al.
    Diagnostic cytopathology, 35(8), 493-497 (2007-07-20)
    The purpose of this study was to test napsin A as a diagnostic marker of metastatic lung adenocarcinoma in pleural effusions, and to compare its performance with TTF-1. Napsin A and TTF-1 reactivities were determined immunohistochemically on formalin-fixed paraffin embedded
    Kentaro Inamura et al.
    The American journal of surgical pathology, 29(5), 660-665 (2005-04-16)
    Primary pulmonary adenocarcinomas with enteric differentiation (PAED) are mainly composed of tall-columnar cells that show similarity to intestinal epithelia and colorectal carcinomas. In this study, we analyzed the immunostaining profiles of 7 PAEDs in comparison with 14 metastatic colorectal carcinomas

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