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C0470000

Carbocisteine

Name: Carbocisteine
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

S-Carboxymethyl-L-cysteine, 3-carboxymethylthio-L-alanine

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About This Item

Fórmula empírica (notación de Hill):

C₅H₉NO₄S

Número de CAS:

638-23-3

Peso molecular:

179.19

Beilstein/REAXYS Number:

1725012

MDL number:

MFCD00002614

UNSPSC Code:

41116107

PubChem Substance ID:

329774796

NACRES:

NA.24

grade

pharmaceutical primary standard

API family

carbocisteine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

N[C@@H](CSCC(O)=O)C(O)=O

InChI

1S/C5H9NO4S/c6-3(5(9)10)1-11-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1

InChI key

GBFLZEXEOZUWRN-VKHMYHEASA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Carbocisteine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

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The effect and mechanism of action of carbocysteine on airway bacterial load in rats chronically exposed to cigarette smoke.

Li Sun et al.

Respirology (Carlton, Vic.), 15(7), 1064-1071 (2010-09-03)

Carbocysteine (S-carboxymethylcysteine) is a mucoactive drug with in vitro free radical scavenging and anti-inflammatory properties. Several clinical trials have indicated that carbocysteine reduces exacerbation rates in COPD. In the present study, the effect of carbocysteine on the airway load of

l-carbocisteine inhibits respiratory syncytial virus infection in human tracheal epithelial cells.

Masanori Asada et al.

Respiratory physiology & neurobiology, 180(1), 112-118 (2011-11-15)

To examine the effects of l-carbocisteine on airway infection with respiratory syncytial (RS) virus, human tracheal epithelial cells were pretreated with l-carbocisteine and infected with RS virus. Viral titer, virus RNA, and pro-inflammatory cytokine secretion, including interleukin (IL)-1 and IL-6

Efficacy of combined treatment with S-carboxymethylcysteine (carbocisteine) and clarithromycin in chronic rhinosinusitis patients without nasal polyp or with small nasal polyp.

Yuichi Majima et al.

Auris, nasus, larynx, 39(1), 38-47 (2011-06-04)

In Japan, fourteen-membered ring macrolides, antibacterial agents, and S-carboxymethylcysteine (SCMC; carbocisteine), a mucolytic, are commonly used to treat chronic rhinosinusitis (CRS), and they are also used in combination. However, no large-scale randomized study has examined the effects of these pharmacotherapies.

A definite case of (L)-carbocisteine-induced pneumonia with CATCH22 syndrome.

Kenichiro Kudo et al.

Internal medicine (Tokyo, Japan), 52(1), 97-100 (2013-01-08)

A 32-year-old male with CATCH22 syndrome presented with a high fever and productive cough after taking drugs for acute bronchitis, including (L)-carbocisteine. Chest radiography revealed ground-glass opacities in the bilateral lung fields. He had a history of similar pneumonia. Under

Drug fever due to S-carboxymethyl-L-cystein: demonstration of a causative agent with patch tests.

Mayumi Hatakeyama et al.

The Journal of dermatology, 39(6), 555-556 (2011-09-29)

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