MABN652

Anti-Potassium Channel Kvβ2 Antibody

clone K17/70, from mouse

• UNSPSC Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• biological source: mouse
• Quality Level: 100
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: K17/70, monoclonal
• species reactivity: rat, human
• species reactivity (predicted by homology): mouse (based on 100% sequence homology)
• technique(s): immunocytochemistry: suitable; immunohistochemistry: suitable; western blot: suitable
• isotype: IgG1κ
• NCBI accession no.: NP_059000
• UniProt accession no.: P62483
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: mouse ... Kcnab2(16498)

Descripción

General description

Voltage-gated potassium channel subunit beta-2, also known as Potassium Channel Kv-Beta-2 or K(+) channel subunit beta-2 or Kv-beta-2, and encoded by the gene Kcnab2/Ckbeta2/Kcnb3, is part of the multi-subunit complex that comprises the potassium ion channel. Potassium Channel Kv-Beta-2 modulates the activity of the pore-forming alpha subunit of the potassium channel. Additionally, Potassium Channel Kv-Beta-2 forms heteromultimeric complexes with not only alpha subunits but also with kinase complexes such as PRKCZ and sequestosome complexes SQSTM1. Potassium Channel Kv-Beta-2 is localized to the plasma membrane and cytoplasm.

Specificity

Other homologies: 100% homology to mouse KvB2.

This antibody does not cross react with Potassium Channel KvBeta1 or Potassium Channel Kv2.1 (Rhodes, K., et al. (1996). Journal of Neuro. 16(16):4846-4860).

Immunogen

Recombinant protein corresponding to rat Potassium Channel Kvβ2.

Application

Detect Kv β2 using this mouse monoclonal antibody, Anti-Potassium Channel Kvβ2 Antibody validated for use in western blotting, IHC & ICC.

Immunocytochemistry Analysis: A representative lot detected Potassium Channel Kvβ2 in mammalian hippocampal neurons (Bu, C., et al. (2006). Neuron 52(5):803-816).
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Potassium Channel Kvβ2 in human cerebellum, rat cerebellum, human cerebral cortex, and rat hindbrain tissue.

Research Category
Neuroscience

Research Sub Category
Developmental Signaling

Quality

Evaluated by Western Blotting in SK-Mel-28 cell lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected Potassium Channel Kvβ2 in 10 µg of SK-Mel-28 cell lysate.

Target description

~39 kDa observed

Physical form

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable