5.04042

Doxorubicin Hydrochloride

InSolution, ≥98%

• Sinónimos: InSolution Doxorubicin, Hydrochloride, Adriamycin, HCl, 14-Hydroxydaunomycin, HCl
• Fórmula empírica (notación de Hill): C₂₇H₂₉NO₁₁ · xHCl
• Número de CAS: 25316-40-9
• Peso molecular: 543.52 (free base basis)
• MDL number: MFCD00077757
• UNSPSC Code: 12352101

Propiedades

• Quality Level: 200
• assay: ≥98% (HPLC)
• form: liquid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; avoid repeated freeze/thaw cycles; protect from light
• storage temp.: −70°C
• InChI: 1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10?,13?,15-,17?,22?,27-;/m0./s1
• InChI key: MWWSFMDVAYGXBV-FGBJBKNOSA-N

Descripción

General description

A 10 mM (5 mg/862 µL) sterile-filtered solution of Doxorubicin, HCl in H₂O.

An anti-tumor antibiotic and a highly effective myotoxin that inhibits topoisomerase II (IC₅₀ = 100 nM). Binds to nucleic acids, presumably by specific intercalation into the DNA double helix, inhibiting nucleic acid synthesis. Cytotoxicity seems to be due to its ability to intercalate with DNA, interact with plasma membranes, and take part in oxidation-reduction reactions. Induces apoptosis in rhabdomyosarcoma cell lines.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Physical form

A 10 mM (5 mg/862 µL) sterile-filtered solution of Doxorubicin, HCl (Cat. No. 324380) in H₂O.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C or -70°C). Aliquots are stable for up to 3 months at -20°C or for up to 6 months at -70°C.

Other Notes

A′Hern, R.P., and Gore, M.E. 1995.J. Clin. Oncol.13, 726.
Nooter, K., et al. 1995. Br. J. Cancer71, 556.
Noviello, E., et al. 1994. Mutat. Res.. 311, 21.
Anderson, R.D., et al. 1993. Mutat. Res.294, 215.
Hershko, C., et al. 1993. J. Lab. Clin. Med.122, 245.
Jongmans, W., et al. 1993. Mutat. Res.294, 207.
O′Shaughnessy, J.A., and Cowan, K.H. 1993. J. Am. Med. Assoc.270, 2089.
Theyer, G., et al. 1993. J. Urol.150, 1544.
Tritton, T.R., and Yee, G. 1982. Science217, 248.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany