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T-073

Supelco

L-Tiroxina

100 μg/mL in methanol with 0.1N NH3, ampule of 1 mL, certified reference material, Cerilliant®

Sinónimos:

3,3′,5,5″-Tetrayodo-L-tironina, 3-[4-(4-Hidroxi-3,5-diyodofenoxi)-3,5-diyodofenil]-L-alanina, T4

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About This Item

Fórmula lineal:
HOC6H2(I)2OC6H2(I)2CH2CH(NH2)CO2H
Número de CAS:
51-48-9
Peso molecular:
776.87
Beilstein/REAXYS Number:
2228515
MDL number:
MFCD00002595
UNSPSC Code:
41116107
PubChem Substance ID:
329826617
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

100 μg/mL in methanol with 0.1N NH3

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

mp

223 °C (dec.) (lit.)

application(s)

clinical testing
clinical testing

format

single component solution

storage temp.

−20°C

SMILES string

N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O

InChI

1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1

InChI key

XUIIKFGFIJCVMT-LBPRGKRZSA-N

Gene Information

human ... THRA(7067) , THRB(7068)

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General description

Thyroxine or T4 is a thyroid hormone responsible for regulation of the body′s basal metabolic rate and essential for growth, development and heart and nervous system function. Free and total T4 serum levels are measured by LC-MS/MS for determination of hyper- or hypothyroidism as well as for monitoring treatment with synthetic thyroid hormones. This Certified Spiking Solution® is suitable for use in LC-MS/MS testing methods as starting materials in preparation of linearity standards, calibrators, and controls.

Biochem/physiol Actions

La L-tiroxina (T4) y la triyodo-L-tironina (T3) son hormonas que contienen yodo producidas a partir de la tiroglobulina en las células foliculares tiroideas. La estimulación de la tasa metabólica y la regulación del crecimiento y el desarrollo por esas hormonas parece deberse a sus efectos sobre la transcripción del ADN y, por tanto, la síntesis de proteínas.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTIONS is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 3 - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes,Central nervous system

Storage Class

3 - Flammable liquids

wgk_germany

WGK 2

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Aleid G van Wassenaer et al.
Clinical endocrinology, 56(5), 621-627 (2002-05-29)
Thyroid hormone is crucial for brain development during foetal and neonatal life. In very preterm infants, transient low levels of plasma T4 and T3 are commonly found, a phenomenon referred to as transient hypothyroxinaemia of prematurity. We investigated whether breast
Steffen Mayerl et al.
The Journal of clinical investigation, 124(5), 1987-1999 (2014-04-03)
Allan-Herndon-Dudley syndrome (AHDS), a severe form of psychomotor retardation with abnormal thyroid hormone (TH) parameters, is linked to mutations in the TH-specific monocarboxylate transporter MCT8. In mice, deletion of Mct8 (Mct8 KO) faithfully replicates AHDS-associated endocrine abnormalities; however, unlike patients
B Velkeniers et al.
Human reproduction update, 19(3), 251-258 (2013-01-19)
BACKGROUND Previous meta-analyses of observational data indicate that pregnant women with subclinical hypothyroidism have an increased risk of adverse pregnancy outcome. Potential benefits of levothyroxine (LT4) supplementation remain unclear, and no systematic review or meta-analysis of trial findings is available
Shannon E Scratch et al.
Pediatrics, 133(4), e955-e963 (2014-04-02)
Preterm infants commonly have transient hypothyroxinemia of prematurity after birth, which has been associated with deficits in general intellectual functioning, memory, attention, and academic achievement. However, research has predominantly focused on thyroxine levels in the first 2 weeks of life
Sonja Heyerdahl et al.
Thyroid : official journal of the American Thyroid Association, 13(11), 1029-1038 (2003-12-04)
Neonatal screening programs for congenital hypothyroidism (CH) were initiated in the 1970s to ensure early treatment in order to prevent mental retardation. With screening, developmental prognosis is considerably improved, but follow-up studies still report developmental delay compared to controls. To
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Protocolos

Online SPE/LC-MS Method for the Rapid Analysis of Thyroid Hormones in Plasma

Determination of the thyroid hormones T4, T3 and rT3 from plasma using an Ascentis Express RP-Amide cartridge to trap the analytes, and a Phenyl-Hexyl column to resolve them.

Online Solid Phase Extraction and LC-MS Analysis of Thyroid Hormones in Human Serum

Thyroid hormones play critical roles in the regulation of biological processes, such as growth, metabolism, protein synthesis, and brain development. For a clinical laboratory, fast and reliable measurements of total hormone levels are important for the diagnosis and monitoring of thyroid diseases.

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