I-015
Itraconazole solution
2.0 mg/mL (Methanol with 1% 1M HCl), ampule of 1 mL, certified reference material, Cerilliant®
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About This Item
Fórmula empírica (notación de Hill):
C35H38Cl2N8O4
Número de CAS:
Peso molecular:
705.63
UNSPSC Code:
41116107
NACRES:
NA.24
Productos recomendados
grade
certified reference material
Quality Level
form
liquid
feature
(Snap-N-Spike®)
packaging
ampule of 1 mL
manufacturer/tradename
Cerilliant®
concentration
2.0 mg/mL (Methanol with 1% 1M HCl)
technique(s)
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
application(s)
clinical testing
format
single component solution
storage temp.
−20°C
InChI
1S/C35H38Cl2N8O4/c1-3-25(2)45-34(46)44(24-40-45)29-7-5-27(6-8-29)41-14-16-42(17-15-41)28-9-11-30(12-10-28)47-19-31-20-48-35(49-31,21-43-23-38-22-39-43)32-13-4-26(36)18-33(32)37/h4-13,18,22-25,31H,3,14-17,19-21H2,1-2H3/t25?,31-,35-/m0/s1
InChI key
VHVPQPYKVGDNFY-ZPGVKDDISA-N
General description
Itraconazole is an antifungal drug prescribed for oral or intravenous treatment of fungal infections. The drug is sold under trade names such as Sporanoxor Onmel®. This Certified Spiking Solution® is suitable as starting material for calibrators, controls, or linearity standards for clinical and diagnostic testing or therapeutic drug monitoring of itraconazole in patient blood, serum, or plasma samples by LC-MS/MS or HPLC.
Application
- Enhanced drug delivery: A study by Soe HMSH et al. discusses a synthetic citric crosslinked beta-cyclodextrin derivative designed to improve the solubility, cytotoxicity, and antifungal activity of drugs like Itraconazole. This innovative approach enhances the bioavailability and therapeutic efficacy of antifungal medications, crucial for treating persistent fungal infections (Soe HMSH et al., 2023).
- Novel formulation techniques: Research by Becelaere J et al. explores solvent electrospinning to create amorphous solid dispersions with high Itraconazole content. This method significantly enhances drug loading and release potential, providing new insights into pharmaceutical formulation and controlled drug delivery systems (Becelaere J et al., 2023).
- Pharmaceutical sciences research: A study by Nunes PD et al. uses in vitro tools to predict the bioavailability of amorphous solid dispersions of drugs like Itraconazole. Their work provides crucial mechanistic insights into drug dissolution and permeation, aiding in the optimization of oral dosage forms for enhanced therapeutic effectiveness (Nunes PD et al., 2023).
- Optimization of sustained release formulations: Research by Wang W et al. on optimizing the O/W emulsion solvent evaporation method for Itraconazole microspheres highlights advancements in sustained-release formulations. This approach aims to improve dosing regimens and patient compliance in chronic treatments (Wang W et al., 2023).
Legal Information
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Onmel is a registered trademark of Merz Pharmaceuticals, LLC
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
Related product
Referencia del producto
Descripción
Precios
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
target_organs
Eyes,Central nervous system
Storage Class
3 - Flammable liquids
wgk_germany
WGK 2
flash_point_f
49.5 °F - closed cup
flash_point_c
9.7 °C - closed cup
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Takashi Ishiguro et al.
Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, 47(4), 296-303 (2009-05-22)
We report the case of a 75-year-old woman with mucoid impaction of the bronchi (MIB) due to Schizophyllum commune who improved with itraconazole (ITCZ) administration and relapsed after discontinuation of the drug. She improved again after readministration of ITCZ, and
Ming Yao et al.
Biomedical chromatography : BMC, 23(7), 677-691 (2009-03-25)
Itraconazole represents an important therapeutic option for the treatment of fungal infections. Itraconazole undergoes rapid metabolism to form hydroxyitraconazole, which also contributes to the anti-fungal activity exhibited by the parent compound. Since both itraconazole and hydroxyitraconazole are effective inhibitors of
Johan Maertens et al.
The Journal of antimicrobial chemotherapy, 56 Suppl 1, i33-i38 (2005-08-27)
The incidence of systemic fungal infections has risen sharply in the last two decades, reflecting a rise in the number of patients who are predisposed to these diseases because they are immunosuppressed or immunocompromised. The growing use of intensive chemotherapy
Jodi Lestner et al.
Expert opinion on drug metabolism & toxicology, 9(7), 911-926 (2013-05-07)
Fungal infections are a major source of global morbidity and mortality. Itraconazole is a triazole antifungal agent that is widely used for the prevention and treatment of fungal infection. While newer antifungal agents are now available, itraconazole is an orally
Izumi Kikuchi et al.
European journal of dermatology : EJD, 16(1), 42-47 (2006-01-27)
Potassium iodide, itraconazole (ITCZ), and terbinafine are widely known as oral antifungal agents for the treatment of sporotrichosis. Although potassium iodide has been used as the antifungal agent of first choice in Japan due to its high efficacy, its use
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