870865P

BMP22

Avanti Polar Lipids, powder

• Sinónimos: 4-pentadecylbenzylphosphonic acid
• Fórmula empírica (notación de Hill): C₂₂H₃₉O₃P
• Número de CAS: 1306684-90-1
• Peso molecular: 382.52
• UNSPSC Code: 12352211

Propiedades

• assay: 99% (TLC)
• form: powder
• packaging: pkg of 1 × 1 mg (870865P-1mg); pkg of 1 × 5 mg (870865P-5mg)
• manufacturer/tradename: Avanti Polar Lipids
• lipid type: bioactive lipids
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: CCCCCCCCCCCCCCCC1=CC=C(CP(O)(O)=O)C=C1

Descripción

General description

BMP (bis(monoacylglycerol)phosphate) is synthesized from phosphatidylglycerol (PG) in alveolar macrophages. BMP is a unique phospholipid having a glycerol phosphate ester at sn-1 position rather than sn-3 and has one acyl group attached to each of the glycerol moieties. The acyl groups of BMP is rich in polyunsaturated species.

Biochem/physiol Actions

BMP (bis(monoacylglycerol)phosphate) (BMP) is found in the retinal pigment epithelium of healthy human retina. BMP lipids regulates cholesterol level in endosomes. It is implicated in endosomal/lysosomal storage diseases like Niemann-Pick and neuronal ceroid lipofuscinosis diseases. BMP22/4PBPA is a small molecule inhibitor of autotaxin (ATX). 4PBPA has relatively a longer half-life and also reduces the lysophosphatidic acid concentration in plasma. BMP22 is implicated in reducing the bone erosion and systemic bone loss.

Packaging

5ML Glass Amber Screw Cap Vial (870865P-1MG)

5ML Glass Amber Screw Cap Vial (870865P-5MG)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable