525553
4-Phenyl-1-(2H)-phthalazinone
97%
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About This Item
Fórmula empírica (notación de Hill):
C14H10N2O
Número de CAS:
Peso molecular:
222.24
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Productos recomendados
Quality Level
assay
97%
mp
240-244 °C (lit.)
functional group
phenyl
SMILES string
O=C1NN=C(c2ccccc2)c3ccccc13
InChI
1S/C14H10N2O/c17-14-12-9-5-4-8-11(12)13(15-16-14)10-6-2-1-3-7-10/h1-9H,(H,16,17)
InChI key
XCJLBNVENUPHEA-UHFFFAOYSA-N
General description
4-Phenyl-1-(2H)-phthalazinone can be prepared from hydrazine sulphate and sodium hydroxide.
Application
4-Phenyl-1-(2H)-phthalazinone may be used in the synthesis of 2-chloro-N-(unsubstituted/substitutedphenyl) acetamide.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Wagdy M Eldehna et al.
European journal of medicinal chemistry, 89, 549-560 (2014-12-03)
A novel series of N-substituted-4-phenylphthalazin-1-ones 14a-g bearing different anilines at the N-2 of phthalazin-1-one scaffold via acetyl-flexible linker was designed and synthesized for the development of potential anticancer agents. Compounds 19a-g were synthesized by insertion of methylene (CH2) bridge at
Kazuko Inoue et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(8), 1326-1333 (2014-06-11)
Lenvatinib is a multityrosine kinase inhibitor that inhibits vascular endothelial growth factor receptors, and is being developed as an anticancer drug. P450s are involved in one of the elimination pathways of lenvatinib, and mono-oxidized metabolites, such as N-oxide (M3) and
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