Downstream Process

Large molecule drug discovery begins with identifying the functional therapeutic target (gene/protein) and evaluating its role in the disease of interest.

Home MK-Test-Folder mAbs Development & ManufacturingDownstream Process

Another Headline

Large molecule drug discovery begins with identifying the functional therapeutic target and evaluating its role in the disease of interest. This identification is then followed by characterization of the molecular mechanisms addressed by this target. All targets should be druggable and modulated by the potential therapeutic.

These early phases have been simplified by the advent of various genome engineering and hybridoma techniques, which can be used for biotherapeutic antibody target and lead discovery.

Problem Statement

Uncover, select, and validate new targets with a strong link to disease. Choices made early in the drug discovery process are highly linked to ultimate failure or success in a drug discovery program. Identification of the most suitable, druggable target is key to success. We offer a complete set of curated genome-wide, pathway-specific, and protein family targeting screening tools to facilitate your target discovery

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Downstream Process

Clarification

Affinity Chromatography

Virus Inactivation

Polishing Chromatography

Viral Clearance

Concentration & Diafiltration

Products for Each Step

Special Service Offering

Downstream Process

Optimization of the downstream steps in monoclonal antibody (mAb) processing is critical to ensuring product quality, yield, and sterility. Getting the most out of every step depends on a broad range of products, services, and solutions to meet the different needs of each process.

Subheadline here

Chemicals used in the downstream processing and purification of biologics often have multiple functions that vary by application, complicating selection for manufacturers with specific quality or cost expectations. Our broad portfolio of downstream chemicals streamlines raw material specification with optimized quality attributes for the full range of downstream needs – then goes a step further by seamlessly integrating supply transparency, documentation, good manufacturing practice (GMP), and change control, all tailored to your risk assessments.

Raw materials within our industry-leading Emprove® chemicals portfolio are supported with comprehensive, up-to-date documentation to help you navigate regulatory challenges, manage risks, and improve processes. The portfolio is divided into categories that reflect the specific application needs of drug manufacturers.

Related Categories

Bioprocessing Cell LInes

Bio4C ProcessPad™ software is a data collection, visualization, and analytics

Bioprocessing Single-Use Bioreactors

Bio4C ProcessPad™ software is a data collection, visualization, and analytics

Related Resources

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Why Choose Millipore^® Products

We provide a complete range of high-quality products for accurate, brilliant results in a variety of analytical applications, including HPLC, GC, Karl Fischer titration, elemental trace analysis, classical analysis, air monitoring, food and beverage analysis, and proficiency testing. We also supply a complete range of safety equipment. We provide a complete range of high-quality products for accurate, brilliant results in a variety of analytical applications, including HPLC, GC, Karl Fischer titration, elemental trace analysis, classical analysis, air monitoring, food and beverage analysis, and proficiency testing. We also supply a complete range of safety equipment.

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