Figure 1.BINOL-derived Chiral Phosphoric Acids
One of the earliest demonstrations of chiral phosphoric acid catalysis is the metal-free reduction of imines with an organic reductant (Hantzsch ester) to give enantioenriched amines.1
Figure 2.Reductive Amination
The enantioselective allylation of aldehydes can be accomplished under very mild conditions at non-cryogenic temperature (-30 °C).2
Functionalized indoles3,4 and pyrroles5 can be accessed in enantioenriched form by asymmetric alkylation.
Figure 4.Friedel-Crafts Alkylation