The Baeyer–Villiger reaction involves the oxidation of ketones to esters by C-C bond cleavage of the carbonyl group and the introduction of an oxygen atom adjacent to it.1 This reaction can be accomplished using hydrogen peroxide, 3-chloroperbenzoic acid (m-chloroperoxybenzoic acid), peroxyacetic acid, or peroxytrifluoroacetic acid as the oxidizing agent. This reaction is also useful in the synthesis of lactones (cyclic esters) from cyclic ketones.
Stereospecificity and predictable regiochemistry are important features of the Baeyer–Villiger oxidation reaction. The reaction is regiospecific in nature and depends on the relative migration ability of the substituents attached to the carbonyl group. This reaction was described by Adolf von Baeyer and Victor Villiger in 1899.
An example for Baeyer–Villiger oxidation reaction:
Please consult the Safety Data Sheet for information regarding hazards and safe handling practices.
The Baeyer–Villiger oxidation reaction is useful for the following studies: