Asymmetric counteranion-directed catalysis (ACDC) has a number of valuable applications in enantioselective synthesis.1 Beginning in 2006, Benjamin List2 and others have expanded this field to encompass a broad range of useful transformations.
In 2009, List and coworkers reported that disulfonimide catalyst 790753 can be used to catalyze asymmetric Mukaiyama aldol reactions in up to 94% ee.3 Two years later, this reaction was extended to vinylogous and bisvinylogous reactions as well.4
More recently, 790753 was employed as a Brønsted acid catalyst in the asymmetric Friedel-Crafts alkylation of imines with indoles.5
Finally, disulfonamide catalyst 790842 was successfully employed in the three-component synthesis of homoallylic amines in up to 97% ee.6
To learn more about other products in our catalog that have been established in collaboration Prof. Dr. List, please visit his Professor Product Page.