- The placental interleukin-6 signaling controls fetal brain development and behavior.
The placental interleukin-6 signaling controls fetal brain development and behavior.
Brain, behavior, and immunity (2016-11-14)
Wei-Li Wu, Elaine Y Hsiao, Zihao Yan, Sarkis K Mazmanian, Paul H Patterson
PMID27838335
ABSTRACT
Epidemiological studies show that maternal immune activation (MIA) during pregnancy is a risk factor for autism. However, mechanisms for how MIA affects brain development and behaviors in offspring remain poorly described. To determine whether placental interleukin-6 (IL-6) signaling is required for mediating MIA on the offspring, we generated mice with restricted deletion of the receptor for IL-6 (IL-6Rα) in placental trophoblasts (Cyp19-Cre
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Polyinosinic–polycytidylic acid potassium salt, with buffer salts, TLR ligand tested