- A concise total synthesis of the lichen macrolide (+)-aspicilin.
A concise total synthesis of the lichen macrolide (+)-aspicilin.
Organic letters (2006-10-20)
Christophe Dubost, Istvan E Markó, Thomas Ryckmans
PMID17048862
ABSTRACT
The total synthesis of the polyhydroxylated macrolide (+)-aspicilin 5 is described using as a key step a highly diastereoselective allylation of aldehyde 6 with the uniquely functionalized allylstannane 1. (+)-Aspicilin is obtained in 18 steps and 10% overall yield. [structure: see text]
MATERIALS