Imidazole: a selective inhibitor of thromboxane synthetase.

Prostaglandins (1977-04-01)
S Moncada, S Bunting, K Mullane, P Thorogood, J R Vane, A Raz, P Needleman

Imidazole inhibits the enzymic conversion of the endoperoxides (PGG2 and PGH2) to thromboxane A2 by platelet microsomes (IC50: 22 MICRONG/ML; DETERMINED BY BIOASSAY). The inhibitor is selective, for prostaglandin cyclo-oxygenase is only affected at high doses. Radiochemical data confirms that imidazole blocks the formation of 14C-thromboxane B2 from 14C-PGH2. Several imidazole analogues and other substances were tested but only 1-methyl-imidazole was more potent than imidazole itself. The use of imidazole to inhibit thromboxane formation could help to elucidate the role of thromboxanes in physiology or pathophysiology.

Product Number
Product Description

Imidazole, ACS reagent, ≥99% (titration)