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Control of IRF-3 activation by phosphorylation.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research (2002-02-16)
Mitsutoshi Yoneyama, Wakako Suhara, Takashi Fujita
PMID11846977
ABSTRACT

Interferon (IFN) regulatory factor-3 (IRF-3) is a unique member of the IRF family. Its transcriptional activity is regulated solely by posttranslational modifications. We review current knowledge of the mechanism of IRF-3 activation: signalling triggered by infections including viruses and bacteria, phosphorylation of IRF-3 on certain serine residues, homodimer formation, and active holocomplex formation with coactivator CBP/p300.