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Guaifenesin in rhinitis.

Current allergy and asthma reports (2009-02-13)
William Storms, Judith R Farrar
ABSTRACT

Mucus in the airways is a complex mixture of water, lipids, glycoproteins, sugars, and electrolytes that serves as a lubricant for the epithelium. The efficient flow of respiratory mucus is a first level of immune defense that requires an appropriate viscosity and elasticity for optimal barrier and ciliary functions. Thickening and drying of airway mucus by respiratory tract infections, allergies, and drugs can impair evacuation. Tenacious, bothersome mucus is an annoying and frequent symptom of rhinitis that is difficult to manage. Common remedies include adequate hydration through fluid intake and nasal washes. The use of mucoactive agents is controversial due to limited data and equivocal efficacy in available studies. Nonetheless, some patients benefit. This review examines the use of guaifenesin (glyceryl guaiacolate) on bothersome nasal mucus associated with rhinitis, including the available published data and clinical experience.

MATERIALS
Product Number
Brand
Product Description

Supelco
Guaifenesin, certified reference material, pharmaceutical secondary standard
USP
Guaifenesin, United States Pharmacopeia (USP) Reference Standard
Guaifenesin, European Pharmacopoeia (EP) Reference Standard
Sigma-Aldrich
Guaiacol glyceryl ether, ≥98% (GC)