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  • The sensitizing capacity of the antioxidants propyl, octyl, and dodecyl gallate and some related gallic acid esters.

The sensitizing capacity of the antioxidants propyl, octyl, and dodecyl gallate and some related gallic acid esters.

Contact dermatitis (1992-04-01)
B M Hausen, W Beyer
ABSTRACT

8 alkyl gallates, including the widely used antioxidants propyl, octyl, and dodecyl (= lauryl) gallate, have been subjected to experimental sensitization in guinea pigs. Using a modern sensitization procedure, the results showed that all gallates are moderate to strong contact sensitizers: dodecyl (= lauryl) gallate was found to be the strongest. A characteristic correlation between side chain length and mean response was observed, giving a maximum of sensitization at a length of 12 carbon atoms (dodecyl gallate). A literature review revealed that the frequency of reports of allergic contact dermatitis from antioxidants of the gallate type has increased in the last 4 years. In most cases, the moderate sensitizer propyl gallate was the source of sensitization.

MATERIALS
Product Number
Brand
Product Description

Dodecyl gallate, European Pharmacopoeia (EP) Reference Standard
Sigma-Aldrich
Gallic acid, 97.5-102.5% (titration)
Sigma-Aldrich
Lauryl gallate, antioxidant, ≥99.0% (HPLC)
Supelco
Gallic acid, certified reference material, TraceCERT®
Supelco
Lauryl gallate, analytical standard