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GC-MS analysis of breath odor compounds in liver patients.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (2008-10-22)
Sandra Van den Velde, Frederik Nevens, Paul Van Hee, Daniel van Steenberghe, Marc Quirynen
ABSTRACT

Liver diseases can cause a sweet, musty aroma of the breath, called fetor hepaticus. Even in a stage of cirrhosis, the disease can be asymptomatic for many years. Breath analysis might be helpful to detect occult liver pathology. This study examined whether specific breath odor compounds can be found in liver patients, suffering from cirrhosis, which might be useful for diagnosis. Fifty-two liver patients and 50 healthy volunteers were enrolled. Alveolar air was analyzed by gas chromatography-mass spectrometry. Using discriminant analysis a model for liver disease was built. Dimethyl sulfide, acetone, 2-butanone and 2-pentanone were increased in breath of liver patients, while indole and dimethyl selenide were decreased. Sensitivity and specificity of the model were respectively 100% and 70%. Fetor hepaticus is caused by dimethyl sulfide and to a lower extent by ketones in alveolar air. Breath analysis by GC-MS makes it possible to discriminate patients with breath malodor related to hepatic pathologies.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Dimethyl selenide, ≥99.0% (GC)