- Direct ortho-arylation of ortho-substituted benzoic acids: overriding Pd-catalyzed protodecarboxylation.
Direct ortho-arylation of ortho-substituted benzoic acids: overriding Pd-catalyzed protodecarboxylation.
Organic letters (2013-02-05)
Carlos Arroniz, Alan Ironmonger, Gerry Rassias, Igor Larrosa
PMID23373630
ABSTRACT
ortho-Arylation of ortho-substituted benzoic acids is a challenging process due to the tendency of the reaction products toward Pd-catalyzed protodecarboxylation. A simple method for preventing decarboxylation in sterically hindered benzoic acids is reported. The method described represents a reliable and broadly applicable entry to 2-aryl-6-substituted benzoic acids.
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
Potassium carbonate, puriss., meets analytical specification of Ph. Helv., anhydrous, granulated, 99-101% (calc. to the dried substance)
Sigma-Aldrich
Potassium carbonate, anhydrous, free-flowing, −325 mesh, Redi-Dri™, reagent grade, ≥98%