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Synthesis of tetraglucosyl- and tetrapolyamine-tetrabenzoporphyrin conjugates for an application in PDT.

Bioorganic & medicinal chemistry (2009-10-13)
Florian Ménard, Vincent Sol, Cyril Ringot, Robert Granet, Sandra Alves, Caroline Le Morvan, Yves Queneau, Noboru Ono, Pierre Krausz
ABSTRACT

This paper reports the synthesis and characterization of a new class of tetrabenzoporphyrins bearing glucosyl or polyamine units on meso positions to improve the targeting of cancer cells. Photocytotoxic activity of these photosensitizers was tested on cell lines HaCaT and MCF-7 and compared to Photofrin II.

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Eosin Y, Dye content ~99 %