Nanomaterials as alternative dispersants for the multiresidue analysis of phthalates in soil samples using matrix solid phase dispersion prior to ultra-high performance liquid chromatography tandem mass spectrometry.

In this study, the application of different nanomaterials as dispersants in matrix solid phase dispersion has been evaluated for the extraction of fifteen phthalates from different environmental samples prior to their separation and quantification by ultra-high performance liquid chromatography coupled to triple quadrupole mass spectrometry. Within the evaluated nanomaterials, including graphene oxide, multi-walled carbon nanotubes and iron 1,3,5-benzenetricarboxylate metal-organic framework, the last one showed the best results in terms of extraction capacity and sample clean-up. The effects of the different parameters affecting the sample pretreatment efficiency were exhaustively evaluated. The whole methodology was validated for agricultural soil and sand, using dibutyl phthalate-3,4,5,6-d4 as surrogate. Recovery values ranged from 70 to 120% for both matrices with RSD values lower than 20% and the limits of quantification of the method achieved were in the range 0.14-2.7 μg/kg dry weight. Finally, the analysis of soil samples from different locations of Tenerife (Canary Islands, Spain) was carried out finding the presence of BBP, DIBP and DBP in the range 5-52 μg/kg dry weight in agricultural soils, and DIPP, DNOP and DINP in the range 2-101 μg/kg dry weight in sand samples.