Cross-coupling reactions are transition metal catalyzed synthetic transformations used extensively to form complex molecules from simple ones. Although used to form C-O, C-N, and C-S bonds also, they are very important carbon–carbon bond formation reactions.
Numerous research groups have developed new metal complexes and ligands, expanding the scope of these transformations to form more complex molecules. Among these some of the important reactions that stand out, include Suzuki-Miyaura reaction, Negishi coupling, Heck reaction, Kumada coupling, Stille cross-coupling, Sonogashira coupling, and Buchwald Hartwig amination reaction. Furthermore, scientists have developed new transition metal complexes that can catalyze these reactions with high yield and low catalyst loading. Several of them enable these reactions to be carried out under mild reaction conditions, with high activity and high turnover numbers. Many of these transition metal catalysts have also successfully transitioned into industry, catalyzing cross-coupling reactions on a ton scale.
We are dedicated to supporting all your needs with a comprehensive cross-coupling catalysts portfolio.
MPhos is a new class of unsymmetrical bis-phosphino ferrocene ligands that can be used in a variety of cross-coupling reactions. The ligand scaffold includes a bulky di(1-adamantyl)phosphino motif as well as a tunable second phosphine. Demonstrated applications include many types of Csp2-Csp3 couplings (i.e. Murahashi−Feringa (Li), Kumada−Corriu (Mg), Negishi (Zn) and Suzuki−Miyaura (B)) with broad substrate scope including many “drug-like” molecules. Learn more here.
The palladium catalyst is extremely versatile due to its ability to fine-tune reaction conditions (temperature, solvents, ligands, bases, and other additives). Furthermore, palladium catalysts have a very high tolerance for various functional groups and often provide excellent stereo- and regio- specificity, which avoids the need of protecting groups. We offer an extensive portfolio of homogeneous and heterogeneous palladium catalysts.
We offer an extensive and high-purity selection of Ni catalysts for use in cross-coupling reactions. These nickel catalysts span a range of oxidation states: Nickel (0), nickel (II), nickel (III) and nickel (IV). Ni catalysts available for immediate purchase are aluminum nickel (Al Ni) alloys, ammonium nickel hydrates, Ni COD, Ni halides (chlorides, bromides, fluorides and iodides), Ni cyclopentadienyls, nickel metal, nickel acac, and Raney Nickel.