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Stradiotto Group – Professor Product Portal

Professor Mark Stradiotto

Professor Mark Stradiotto

The main focus of the Stradiotto group has centered on the development and application of novel electronically rich, sterically encumbered P,N-based ancillary ligands for use in late metal catalysis, including Pd and Au chemistry. To this end, the Stradiotto group has developed the DalPhos series of ligands, of which Me-DalPhos (751413) and Mor-DalPhos (751618) in particular have led to considerable improvements in ubiquitous and/or challenging catalytic transformations, including the Buchwald-Hartwig Amination reaction and alkyne hydroamination. The DalPhos ligands not only engage classically difficult reaction partners (often at ambient temperature) but have also been applied successfully to a variety of synthetic challenges, such as the monoarylation of ammonia, hydrazine, and acetone. The Stradiotto group also established the applicability of the DalPhos ligand class in Au-catalyzed hydroamination chemistry involving challenging reaction pairings including the addition of secondary dialkylamines to internal alkynes.

Landmark publications and the latest developments from the Stradiotto group are accessible through the links provided below. For further examples of the versatility of the DalPhos ligands developed by the Stradiotto group, please refer to the work highlighted by the Zhang Group.

Stradiotto Group website

Recent papers from the Stradiotto Group

1.
Hesp KD, Stradiotto M. 2010. Stereo- and Regioselective Gold-Catalyzed Hydroamination of Internal Alkynes with Dialkylamines. J. Am. Chem. Soc.. 132(51):18026-18029. http://dx.doi.org/10.1021/ja109192w
2.
Lundgren R, Peters B, Alsabeh P, Stradiotto M. 2010. A P,N-Ligand for Palladium-Catalyzed Ammonia Arylation: Coupling of Deactivated Aryl Chlorides, Chemoselective Arylations, and Room Temperature Reactions. Angewandte Chemie International Edition. 49(24):4071-4074. http://dx.doi.org/10.1002/anie.201000526
3.
Hesp KD, Lundgren RJ, Stradiotto M. 2011. Palladium-Catalyzed Mono-?-arylation of Acetone with Aryl Halides and Tosylates. J. Am. Chem. Soc.. 133(14):5194-5197. http://dx.doi.org/10.1021/ja200009c
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DISCIPLINES

  • Organic Synthetic Chemistry
  • Catalysis

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