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Ngai Group – Professor Product Portal

Professor Ming-Yu Ngai

Ngai Lab focuses on the development of novel reagents and radical strategies to access open-shell reactive species for the formation of carbon-carbon and carbon-heteroatom bonds. Redox-active di- and trifluoromethoxylating reagents have been developed for direct conversion of (hetero)aryl C-H group into C-OCF2H and C-OCF3 groups. The mild reaction conditions tolerate a wide range of functional groups and enable late-stage functionalization of drug-like molecules..

Ngai Group Website

Recent papers from the Ngai Group

1.
Zheng W, Lee JW, Morales?Rivera CA, Liu P, Ngai M. 2018. Redox?Active Reagents for Photocatalytic Generation of the OCF 3 Radical and (Hetero)Aryl C?H Trifluoromethoxylation. Angew. Chem. Int. Ed.. 57(42):13795-13799. http://dx.doi.org/10.1002/anie.201808495
2.
Lee JW, Lee KN, Ngai M. 2019. Synthesis of Tri? and Difluoromethoxylated Compounds by Visible?Light Photoredox Catalysis. Angew. Chem. Int. Ed.. 58(33):11171-11181. http://dx.doi.org/10.1002/anie.201902243
3.
Lee J, Zheng W, Morales-Rivera CA, Liu P, Ngai M. Catalytic radical difluoromethoxylation of arenes and heteroarenes. Chem. Sci.. 10(11):3217-3222. http://dx.doi.org/10.1039/c8sc05390a

DISCIPLINES

  • Organic Synthetic Chemistry
  • Chemical Biology

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