Ngai Lab focuses on the development of novel reagents and radical strategies to access open-shell reactive species for the formation of carbon-carbon and carbon-heteroatom bonds. Redox-active di- and trifluoromethoxylating reagents have been developed for direct conversion of (hetero)aryl C-H group into C-OCF2H and C-OCF3 groups. The mild reaction conditions tolerate a wide range of functional groups and enable late-stage functionalization of drug-like molecules..
Ngai Group Website