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Ngai Group – Professor Product Portal

Professor Ming-Yu Ngai

Ngai Lab focuses on the development of novel reagents and radical strategies to access open-shell reactive species for the formation of carbon-carbon and carbon-heteroatom bonds. Redox-active di- and trifluoromethoxylating reagents have been developed for direct conversion of (hetero)aryl C-H group into C-OCF2H and C-OCF3 groups. The mild reaction conditions tolerate a wide range of functional groups and enable late-stage functionalization of drug-like molecules..

Ngai Group Website

Recent papers from the Ngai Group

Zheng W, Lee JW, Morales?Rivera CA, Liu P, Ngai M. 2018. Redox?Active Reagents for Photocatalytic Generation of the OCF 3 Radical and (Hetero)Aryl C?H Trifluoromethoxylation. Angew. Chem. Int. Ed.. 57(42):13795-13799.
Lee JW, Lee KN, Ngai M. 2019. Synthesis of Tri? and Difluoromethoxylated Compounds by Visible?Light Photoredox Catalysis. Angew. Chem. Int. Ed.. 58(33):11171-11181.
Lee J, Zheng W, Morales-Rivera CA, Liu P, Ngai M. Catalytic radical difluoromethoxylation of arenes and heteroarenes. Chem. Sci.. 10(11):3217-3222.


  • Organic Synthetic Chemistry
  • Chemical Biology

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