Professor Louie's research focuses on the discovery and mechanistic understanding of new reactions catalyzed by transition metal complexes. She has developed a highly active Ni(0) catalyst that effectively mediates a variety of cycloaddition and isomerization reactions. For example, her group developed a series of Ni(0) catalysts that mediate the cycloaddition between unsaturated hydrocarbons (e.g. diynes, enynes, alkynes) and heterocumulenes (such as CO2 and isocyanates) as well as other derivatives (such as aldehydes, ketones, nitriles, azetidinones) to afford a variety of substituted heterocycles. The Ni catalyzed coupling of an alkyne and an azetidinone affords 3-piperidones, a N-heterocyclic building block that is difficult to make by traditional methods.
Louie Group Website