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Krische Group – Professor Product Portal

Professor Michael Krische

Professor Michael Krische

The Krische group has developed a broad class of “C-C bond forming transfer hydrogenations” wherein the exchange of hydrogen between alcohols and unsaturated reactants serves to generate aldehyde-organometal pairs that combine to give products of carbonyl addition. This methodology enables direct alcohol CH-functionalization, avoiding discrete alcohol-to-aldehyde redox manipulations. The indicated cyclometallated iridium C,O-benzoate complexes can be handled on the bench top and deployed in aqueous organic media.

Krische Group Website

Recent papers from the Krische Group

Han SB, Gao X, Krische MJ. 2010. Iridium-Catalyzedanti-Diastereo- and Enantioselective Carbonyl (Trimethylsilyl)allylation from the Alcohol or Aldehyde Oxidation Level. J. Am. Chem. Soc.. 132(26):9153-9156. http://dx.doi.org/10.1021/ja103299f
Zhang YJ, Yang JH, Kim SH, Krische MJ. 2010. anti-Diastereo- and Enantioselective Carbonyl (Hydroxymethyl)allylation from the Alcohol or Aldehyde Oxidation Level: Allyl Carbonates as Allylmetal Surrogates. J. Am. Chem. Soc.. 132(13):4562-4563. http://dx.doi.org/10.1021/ja100949e
Gao X, Han H, Krische MJ. 2011. Direct Generation of Acyclic Polypropionate StereopolyadsviaDouble Diastereo- and Enantioselective Iridium-Catalyzed Crotylation of 1,3-Diols: Beyond Stepwise Carbonyl Addition in Polyketide Construction. J. Am. Chem. Soc.. 133(32):12795-12800. http://dx.doi.org/10.1021/ja204570w
Han SB, Han H, Krische MJ. 2010. Diastereo- and Enantioselectiveanti-Alkoxyallylation Employing Allylicgem-Dicarboxylates as Allyl Donors via Iridium-Catalyzed Transfer Hydrogenation. J. Am. Chem. Soc.. 132(6):1760-1761. http://dx.doi.org/10.1021/ja9097675
Han SB, Kim IS, Han H, Krische MJ. 2009. Enantioselective Carbonyl Reverse Prenylation from the Alcohol or Aldehyde Oxidation Level Employing 1,1-Dimethylallene as the Prenyl Donor. J. Am. Chem. Soc.. 131(20):6916-6917. http://dx.doi.org/10.1021/ja902437k
Gao X, Townsend IA, Krische MJ. 2011. Enhanced anti-Diastereo- and Enantioselectivity in Alcohol-Mediated Carbonyl Crotylation Using an Isolable Single Component Iridium Catalyst. J. Org. Chem.. 76(7):2350-2354. http://dx.doi.org/10.1021/jo200068q


  • Organic Synthetic Chemistry

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