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Herzon Group – Professor Product Portal

Professor Seth Herzon

Professor Seth Herzon

The Herzon group has developed highly active catalysts for the anti-Markovnikov hydration and reductive hydration of terminal alkynes to form aldehydes and linear alcohols, respectively. The reductive hydration reaction proceeds by formation of an aldehyde intermediate that is reduced in situ. The catalysts 794120 and 794139, and the dry mixture of ligand and catalyst L511692, are air- and moisture stable. All reactions should be performed in deoxygenated solvents.

Herzon Group Website

Recent papers from the Herzon Group

1.
Li L, Herzon SB. 2014. Temporal separation of catalytic activities allows anti-Markovnikov reductive functionalization of terminal alkynes. Nature Chem. 6(1):22-27. http://dx.doi.org/10.1038/nchem.1799
2.
Li L, Zeng M, Herzon SB. 2014. Broad-Spectrum Catalysts for the Ambient Temperature Anti-Markovnikov Hydration of Alkynes. Angew. Chem. Int. Ed.. 53(30):7892-7895. http://dx.doi.org/10.1002/anie.201404320
3.
Zeng M, Li L, Herzon SB. 2014. A Highly Active and Air-Stable Ruthenium Complex for the Ambient Temperature Anti-Markovnikov Reductive Hydration of Terminal Alkynes. J. Am. Chem. Soc.. 136(19):7058-7067. http://dx.doi.org/10.1021/ja501738a
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DISCIPLINES

  • Organic Synthetic Chemistry
  • Catalysis

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