The Garg Group develops methods for the synthesis of natural products and pharmaceuticals. One key method pertains to heterocyclic arynes, such as indolynes and pyridynes, which are generated in situ from silyltriflate precursors under mild fluoride based reaction conditions. Heterocyclic arynes can be trapped by a variety of reagents (e.g., nucleophiles and cycloaddition partners) to prepare diverse libraries of substituted heterocycles from common precursors. The Garg lab has also collaborated with Professor Ken Houk to develop the aryne distortion model, which in turn allows chemists to predict regioselectivity in reactions of unsymmetrical arynes.
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