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Brian Frost

Professor Brian Frost

The Frost group has a longstanding interest in aqueous phase organometallic chemistry with an emphasis on water-soluble phosphine ligands. One focus of this research group has been centered on the chemistry of the neutral, air stable, and water-soluble heterocyclic phosphine 1,3,5-Triaza-7-phosphaadamantane (PTA). PTA is a small phosphine ligands with a cone angle of ~103°. PTA binds metal centers quite strongly and is electronically more donating than PPh3. Ruthenium complexes of PTA have exhibited impressive anticancer activity. A wide variety of transition metal complexes of PTA have been utilized as catalysts for reactions such as hydrogenation, C-C bond forming reactions, atom transfer radical addition, and nitrile hydration.

Frost Group Website

Recent papers from the Frost Group

Wong GW, Harkreader JL, Mebi CA, Frost BJ. 2006. Synthesis and Coordination Chemistry of a Novel Bidentate Phosphine:  6-(Diphenylphosphino)-1,3,5-triaza-7-phosphaadamantane (PTA-PPh2). Inorg. Chem.. 45(17):6748-6755. http://dx.doi.org/10.1021/ic060576a
Frost BJ, Bautista CM, Huang R, Shearer J. 2006. Manganese Complexes of 1,3,5-Triaza-7-phosphaadamantane (PTA): The First Nitrogen-Bound Transition-Metal Complex of PTA. Inorg. Chem.. 45(9):3481-3483. http://dx.doi.org/10.1021/ic060322p
Products available from the Frost Group


  • Catalysis
  • Organic Synthetic Chemistry

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