1268808

依托泊苷

United States Pharmacopeia (USP) Reference Standard

• 同義詞: 4′-去甲基表鬼臼毒素 -(4,6-O-亚乙基-β-D-吡喃葡萄糖苷), VP-16-213
• 經驗公式（希爾表示法）: C₂₉H₃₂O₁₃
• CAS號碼: 33419-42-0
• 分子量：: 588.56
• MDL號碼: MFCD00869325
• 分類程式碼代碼: 41116107
• PubChem物質ID: 329749817
• NACRES: NA.24

屬性

• 等級: pharmaceutical primary standard
• API 家族: etoposide
• 製造商／商標名: USP
• 應用: pharmaceutical (small molecule)
• 格式: neat
• 儲存溫度: 2-8°C
• SMILES 字串: COc1cc(cc(OC)c1O)[C@H]2[C@@H]3[C@H](COC3=O)[C@H](O[C@@H]4O[C@@H]5CO[C@@H](C)O[C@H]5[C@H](O)[C@H]4O)c6cc7OCOc7cc26
• InChI: 1S/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3/h4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3/t11-,15+,20-,21-,22+,24-,25-,26-,27-,29+/m1/s1
• InChI 密鑰: VJJPUSNTGOMMGY-MRVIYFEKSA-N
• 基因資訊: human ... TOP2A(7153) , TOP2B(7155)

描述

一般說明

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

應用

Etoposide USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Etoposide Capsules
• Etoposide Injection
• Etoposide Phosphate
• Etoposide Phosphate for Injection

生化／生理作用

依托泊甙是一种抗肿瘤试剂，和拓扑异构酶II和DNA结合，增强DNA双链和单链剪切和可逆抑制解除。 在S期和G2期阻止细胞周期；诱导正常和肿瘤细胞系凋亡；抑制癌蛋白Mdm2的合成，引起Mdm2过量表达的肿瘤系细胞凋亡。

分析報告

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他說明

Sales restrictions may apply.

安全資訊

• 象形圖: GHS08,GHS07
• 訊號詞: Danger
• 危險聲明: H302,H350,H361d
• 防範說明: P202 - P264 - P270 - P280 - P301 + P312 - P308 + P313
• 危險分類: Acute Tox. 4 Oral - Carc. 1B - Repr. 2
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable