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Merck
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Key Documents

341205

Sigma-Aldrich

依托泊苷

≥95% (HPLC), solid, topoisomerase II inhibitor, Calbiochem

同義詞:

依托泊苷

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About This Item

經驗公式（希爾表示法）:
C29H32O13
CAS號碼:
33419-42-0
分子量：:
588.56
MDL號碼:
MFCD00869325
分類程式碼代碼:
12352200
NACRES:
NA.77

product name

依托泊苷, A cell-permeable derivative of podophyllotoxin that acts as a topoisomerase II inhibitor (IC₅₀ = 59.2 µM) has major activity against a number of tumors, including germ cell neoplasms, small cell lung cancer, and malignant lymphoma.

品質等級

100

化驗

≥95% (HPLC)

形狀

solid

製造商／商標名

Calbiochem®

儲存條件

OK to freeze
protect from light

顏色

white

溶解度

DMSO: 25 mg/mL

運輸包裝

ambient

儲存溫度

10-30°C

InChI

1S/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3/h4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3/t11-,15+,20-,21-,22+,24-,25-,26-,27-,29+/m1/s1

InChI 密鑰

VJJPUSNTGOMMGY-MRVIYFEKSA-N

一般說明

一种细胞可渗透的拓扑异构酶II抑制剂（IC50 = 59.2 µM）。一种鬼臼毒素衍生物（目录编号540040），对许多肿瘤（包括生殖细胞肿瘤、小细胞肺癌和恶性淋巴瘤）具有主要活性。在小鼠胸腺细胞和HL-60人白血病细胞中诱导凋亡。
一种细胞可渗透的鬼臼毒素衍生物，可用作拓扑异构酶II抑制剂（IC50 = 59.2 µM），对许多肿瘤（包括生殖细胞肿瘤、小细胞肺癌和恶性淋巴瘤）具有主要活性。在小鼠胸腺细胞和HL-60人白血病细胞中诱导凋亡。

生化／生理作用

主要靶标
拓扑异构酶2
产物不与ATP竞争。
可逆：否
细胞可渗透性：是
靶标IC50：59.2 µM，抑制拓扑异构酶II

警告

毒性：有害 & 致癌/致畸性（E）

重構

复溶后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。

其他說明

De Lange, A.M., et al. 1995.J. Virol.69, 2082.
Kaufman, S.H., et al. 1993.Cancer Res.53, 3976.
Onishi, Y., et al. 1993.Biochim.Biophys.Acta1175, 147.
Terada, T., et al. 1993.J. Med. Chem. 36, 1689.
Wazniak, A.J., et al. 1991.J. Clin. Oncol.9, 70.
Einhorn, L.H., et al. 1988.J. Clin. Oncol.6, 451.
Issel, B.F.1982.Cancer Chemother.Pharmacol.7, 73.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

象形圖

Health hazardExclamation mark
GHS08,GHS07

訊號詞

Danger

危險聲明

H302,H350,H361d

危險分類

Acute Tox. 4 Oral - Carc. 1B - Repr. 2

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

分析證明 (COA)

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