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V4512

Sigma-Aldrich

Vascular Endothelial Growth Factor from mouse

≥98% (SDS-PAGE), recombinant, expressed in E. coli, powder, suitable for cell culture

同義詞:

mVEGF, VEGF

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About This Item

MDL號碼:
MFCD01636149
分類程式碼代碼:
12352202
NACRES:
NA.77

product name

Vascular Endothelial Growth Factor from mouse, VEGF, recombinant, expressed in E. coli, powder, suitable for cell culture

生物源

mouse

品質等級

100

重組細胞

expressed in E. coli

化驗

≥98% (SDS-PAGE)

形狀

powder

效力

≤10 ng/mL

品質

endotoxin tested

分子量

protein 39 kDa

包裝

pkg of 10 μg
pkg of 50 μg

儲存條件

avoid repeated freeze/thaw cycles

技術

cell culture | mammalian: suitable

雜質

<1 EU/μg

UniProt登錄號

Q00731

儲存溫度

−20°C

基因資訊

mouse ... VEGFA(22339)

一般說明

Vascular endothelial growth factor is also known as VPF, VEGF and MVCD1. It is secreted from endothelial cells and pericytes in response to hypoxia. It helps in inducing angiogenesis and microvascular hyperpermeability. VEGF levels are associated with vasculitic neuropathy and may be used to predict this disease. It may also act as a marker in the development and progression of early precancerous lesions of oesophagus.

應用

Vascular endothelial growth factor (VEGF) supports development of new blood vessels during embryonic development and after vascular injury.Vascular endothelial growth factor from mouse was used for ELISA and in matrigel plugs (matrigel was supplemented with VEGF).

其他說明

Homodimeric protein consisting of two 165 amino acid polypeptide chains of mouse VEGF.
2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

外觀

Lyophilized from a 0.2 μm filtered buffered solution.

分析報告

The biological activity is measured by the ability to stimulate 3H-thymidine incorporation in human umbilical vein endothelial cells (HUVEC) and bovine aortic endothelial cells.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析證明 (COA)

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J Sundaram et al.
Journal of thrombosis and haemostasis : JTH, 12(5), 690-700 (2014-07-01)
Recent studies have shown that factor VIIa binds to endothelial cell protein C receptor(EPCR), a cellular receptor for protein C and activated protein C. At present, the physiologic significance of FVIIa interaction with EPCR in vivo remains unclear. To investigate
Katsuhisa Tashiro et al.
Stem cells and development, 23(18), 2202-2210 (2013-12-19)
Vascular endothelial growth factor (VEGF) is reported to exhibit potent hematopoietic stem/progenitor cell (HSPC) mobilization activity. However, the detailed mechanisms of HSPC mobilization by VEGF have not been examined. In this study, we investigated the effect of VEGF on bone
Asieh Golozar et al.
European journal of cancer (Oxford, England : 1990), 50(16), 2855-2865 (2014-08-31)
Mechanisms involved in wound healing play some role in carcinogenesis in multiple organs, likely by creating a chronic inflammatory milieu. This study sought to assess the role of genetic markers in selected inflammation-related genes involved in wound healing (interleukin (IL)-1a
Benjamin B Bartelle et al.
Circulation research, 110(7), 938-947 (2012-03-01)
The formation and maintenance of a functional vasculature is essential for normal embryonic development, and genetic changes that affect the vasculature underlie pathogenesis in many human diseases. In vivo imaging in mouse models is required to understand the full complexity
Jafar Rezaie et al.
Journal of cellular biochemistry, 119(1), 524-535 (2017-06-14)
This experiment investigated the impact of serum from patients with type 2 diabetes mellitus on the angiogenic behavior of human mesenchymal stem cells in vitro. Changes in the level of Ang-1, Ang-2, cell migration, and trans-differentiation into pericytes and endothelial
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文章

Vascular Endothelial Growth Factors (VEGF)

Vascular endothelial growth factor (VEGF) is a family of closely related growth factors having a conserved pattern of eight cysteine residues and sharing common VEGF receptors. VEGF-A (VEGF) is a potent growth factor for blood vessel endothelial cells, showing pleiotropic responses that facilitate cell migration, proliferation, tube formation, and survival. In the developing embryo VEGF-A mRNA is expressed by cells within tissues undergoing capillarization.

Vascular Endothelial Growth Factors (VEGF)

Vascular endothelial growth factor (VEGF) is a family of closely related growth factors having a conserved pattern of eight cysteine residues and sharing common VEGF receptors. VEGF-A (VEGF) is a potent growth factor for blood vessel endothelial cells, showing pleiotropic responses that facilitate cell migration, proliferation, tube formation, and survival. In the developing embryo VEGF-A mRNA is expressed by cells within tissues undergoing capillarization.

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