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重要文件

V4390

Sigma-Aldrich

VUF 8430二氢溴酸盐

≥97% (NMR)

同義詞:

2-[(Aminoiminomethyl)amino]ethyl carbamimidothioic acid ester, S-(2-guanidylethyl)-isothiourea

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About This Item

經驗公式(希爾表示法):
C4H11N5S· 2HBr
CAS號碼:
分子量::
323.05
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

品質等級

化驗

≥97% (NMR)

形狀

solid

儲存條件

desiccated

溶解度

deionized water: 24 mg/mL

儲存溫度

room temp

SMILES 字串

Br.Br.NC(=N)NCCSC(N)=N

InChI

1S/C4H11N5S.2BrH/c5-3(6)9-1-2-10-4(7)8;;/h1-2H2,(H3,7,8)(H4,5,6,9);2*1H

InChI 密鑰

GPWJSTKHQMIXCA-UHFFFAOYSA-N

生化/生理作用

VUF 8430 dihydrobromide is a potent histamine H4 receptor agonist, with a 33-fold selectivity over the histamine H3 receptor and negligible affinity for the other histamine receptor.

特點和優勢

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

象形圖

Exclamation mark

訊號詞

Warning

危險分類

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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存取文件庫

Tamara E Galarza et al.
Biochemical pharmacology, 180, 114177-114177 (2020-07-30)
Epithelial-mesenchymal transition (EMT) contributes to cell invasion and metastasis during the progression of epithelial cancers. Though preclinical evidence suggests a role for histamine H4 receptor (H4R) in breast cancer growth, its function in the EMT is less known. In this

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