T2573

Troglitazone

≥98% (HPLC), powder, PPARγ agonist

• 同義詞: (±)-5-[4-[(6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy]benzyl]-2,4-thiazolidinedione, CS-045
• 經驗公式（希爾表示法）: C₂₄H₂₇NO₅S
• CAS號碼: 97322-87-7
• 分子量：: 441.54
• MDL號碼: MFCD00878416
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24724629
• NACRES: NA.77

屬性

• product name: Troglitazone, ≥98% (HPLC)
• 品質等級: 200
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to off-white
• 溶解度: DMSO: 20 mg/mL
• SMILES 字串: Cc1c(C)c2OC(C)(CCc2c(C)c1O)COc3ccc(CC4SC(=O)NC4=O)cc3
• InChI: 1S/C24H27NO5S/c1-13-14(2)21-18(15(3)20(13)26)9-10-24(4,30-21)12-29-17-7-5-16(6-8-17)11-19-22(27)25-23(28)31-19/h5-8,19,26H,9-12H2,1-4H3,(H,25,27,28)
• InChI 密鑰: GXPHKUHSUJUWKP-UHFFFAOYSA-N
• 基因資訊: human ... PPARA(5465) , PPARG(5468)

描述

一般說明

Troglitazone is used to treat type 2 diabetes. It is associated with liver injury. Troglitazone functions as an inducer of cytochrome3A.

應用

Troglitazone has been used as a reagent in adipocyte differentiation medium.

生化／生理作用

PPARγ agonist; anti-diabetic thiazolidinedione (TZD) with anti-inflammatory and anti-tumor activity; induces apoptosis via a p53 pathway.

特點和優勢

This compound is featured on the Nuclear Receptors (PPARs) and Potassium Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

準備報告

Studies using troglitazone have reported that it can increase AMP-activated protein kinase (pAMPK) and phosphorylated acetyl-CoA carboxylase in isolated rat extensor digitorum longus muscles¹. Furthermore, analysis of troglitazone-mediated autophagy is reported to correlate with the stimulation of AMPK α².

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)