推薦產品
品質等級
化驗
≥98%
分子量
481.3
儲存溫度
−20°C
SMILES 字串
OC(c1ccc(cc1)N(CC(F)(F)F)S(=O)(=O)c2ccccc2)(C(F)(F)F)C(F)(F)F
InChI
1S/C17H12F9NO3S/c18-14(19,20)10-27(31(29,30)13-4-2-1-3-5-13)12-8-6-11(7-9-12)15(28,16(21,22)23)17(24,25)26/h1-9,28H,10H2
InChI 密鑰
SGIWFELWJPNFDH-UHFFFAOYSA-N
基因資訊
human ... ABCA1(19) , NR1H2(7376) , NR1H3(10062)
應用
T0901317应用于LXR激动剂研究,以观察小鼠所有受膳食胆固醇调节的基因的表达。此外,它还用于刺激WT(野生型)和Tg(转基因)小鼠放射性标记的腹腔巨噬细胞,以便进行细胞胆固醇流出测定。
生化/生理作用
T0901317能通过作用于线粒体代谢来阻止胰岛素的分泌。
LXR激动剂,其治疗导致ABC1基因表达的LXR依赖性上调
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號,寫有 ‘Lot’或‘Batch’.。
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The LXR ligand T0901317 acutely inhibits insulin secretion by affecting mitochondrial metabolism
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The Journal of Biological Chemistry, 280(19), 19410-19418 (2005)
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Inhibition of local macrophage growth ameliorates focal inflammation and suppresses atherosclerosis
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