SML3106

7ACC2

≥98% (HPLC)

• 同義詞: 7-(N-Benzyl-N-methylamino)-2-oxo-2H-chromene-3-carboxylic acid, 7-ACC2, 7-Aminocarboxycoumarin 2, 7-[Benzyl(methyl)amino]-2-oxo-2H-chromene-3-carboxylic acid, 7-[Methyl(phenylmethyl)amino]-2-oxo-2H-1-benzopyran-3-carboxylic acid
• 經驗公式（希爾表示法）: C₁₈H₁₅NO₄
• CAS號碼: 1472624-85-3
• 分子量：: 309.32
• MDL號碼: MFCD28167835
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: 2 mg/mL, clear
• 儲存溫度: 2-8°C
• SMILES 字串: O=C(O)C1=CC2=C(C=C(C=C2)N(C)CC3=CC=CC=C3)OC1=O
• InChI: 1S/C18H15NO4/c1-19(11-12-5-3-2-4-6-12)14-8-7-13-9-15(17(20)21)18(22)23-16(13)10-14/h2-10H,11H2,1H3,(H,20,21)
• InChI 密鑰: XTKDQPFUOFAMRL-UHFFFAOYSA-N

描述

生化／生理作用

7ACC2 is a monocarboxylate transporters MCT1 & MCT4 (SLC16A1 & SLC16A3) inhibitor that affects lactate uptake-dependent cancer growth in cultures (uptake/proliferation IC50 = 59/220 nM; MCT1/4-expressing SiHA cervix cancer in the absence of glucose) and in vivo (3 mg/kg/day i.p.; SiHa, HCT116, MCF-7 in mice), without affecting lactate efflux or the survival of highly glycolytic HL-60 (MCT1) or MDA-MB231 (MCT4) cancer cells. Unlike the MCT1/2 inhibitor AR-C155858, 7ACC2 does not block MCT1-mediated uptake of the anti-cancer drug 3-bromopyruvate (3-BP).

Monocarboxylate transporters MCT1 & MCT4 (SLC16A1 & SLC16A3) inhibitor that blocks lactate update-dependent cancer growth in vitro and in vivo.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable